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GSK872 HCl（1346546-69-7 free base）
CAS No. 2703752-81-0
GSK872 HCl（1346546-69-7 free base）( —— )
Catalog No. M35224 CAS No. 2703752-81-0
GSK872 HCl（1346546-69-7 free base） (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | Get Quote |
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| 5MG | 68 | Get Quote |
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| 10MG | 116 | Get Quote |
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| 25MG | 182 | Get Quote |
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| 50MG | 296 | Get Quote |
|
| 100MG | 446 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK872 HCl（1346546-69-7 free base）
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NoteResearch use only, not for human use.
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Brief DescriptionGSK872 HCl（1346546-69-7 free base） (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
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DescriptionGSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.
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In VitroCell Viability AssayCell Line:HT-29 cells Concentration:0.01, 0.03 , 0.1, 0.3, 1, and 3 μM Incubation Time:24 hours Result:Blocked TNF-induced necroptosis in a concentration-dependent manner.
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In VivoAnimal Model:Eight weeks old Sprague-Dawley male rats with 300-320 g body weight (rat SAH model)Dosage:25 mM/6 μL Administration:Syringe pump (intracerebroventricular) at 30 min after SAHResult:Attenuated brain edema, improved neurological function and decreased the number of necrotic cells in the ipsilateral cortex. Decreased the expression of RIPK3, MLKL and cytoplasmic HMGB1 at 72 h after SAH in the ipsilateral cortex.
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Synonyms——
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number2703752-81-0
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Formula Weight419.94
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Molecular FormulaC19H18ClN3O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (23.81 mM; Ultrasonic (<60°C); H2O : 2.5 mg/mL (5.95 mM; Ultrasonic (<60°C))
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SMILESCl.CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.?
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